Description

Spiro[Benzofuran-3(2H),1'-Cyclopropan]-4-Ol CAS NO 1311139-79-3 is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of complex, bioactive molecules, particularly in modern medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.

Application

This specialized intermediate serves as a key precursor in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in universities and research institutes for studying spirocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	Spiro[Benzofuran-3(2H),1'-Cyclopropan]-4-Ol
CAS No.	1311139-79-3
Molecular Formula	C₁₀H₁₀O₂
Molecular Weight	162.19 g/mol
Synonyms	4-Hydroxyspiro[benzofuran-3(2H),1'-cyclopropane]; Spiro(cyclopropane-1,3'(2'H)-benzofuran)-4-ol; 1'-Cyclopropanespiro[benzofuran-3(2H),4-ol]; 4-Hydroxy-1-oxaspiro[4.4]non-2-en-3-one (tautomeric form); Spirocyclic benzofuranol; CAS 1311139-79-3
EINECS	Contact for details

Quality Control

Our production of Spiro[Benzofuran-3(2H),1'-Cyclopropan]-4-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. The material is manufactured and controlled under a quality system compliant with cGMP principles for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. We support our clients' regulatory filings with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.