Description

S-Acetyl-Peg3-Azido is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a protected thiol group. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise and efficient cross-linking of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science industries for applications such as antibody-drug conjugate (ADC) development, peptide modification, and hydrogel synthesis.

Application

• Bioconjugation and ADC Development: A key building block for constructing antibody-drug conjugates (ADCs) and other targeted therapeutics via copper-free click chemistry with alkynes.
• Peptide and Protein Modification: Used to site-specifically introduce functional handles (azide groups) onto peptides and proteins for further labeling or immobilization.
• Polymer and Dendrimer Synthesis: Serves as a versatile heterobifunctional linker in the stepwise synthesis of functionalized PEG-based polymers and dendrimers.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and other material surfaces with bioactive ligands.
• Hydrogel Formation: Acts as a cross-linking agent in the creation of biocompatible hydrogels for drug delivery and tissue engineering.
• Chemical Biology Probes: Integral for synthesizing activity-based probes and other tools for studying biological processes.

Basic Information

Product Name	S-Acetyl-Peg3-Azido
CAS No.	1310827-26-9
Molecular Formula	C₁₃H₂₅N₃O₆S
Molecular Weight	351.42 g/mol
Synonyms	1-Azido-3,6,9-trioxa-12-thiapentadecan-15-oic acid, 15-acetyl-12-thio-; 15-Acetylthio-3,6,9,12-tetraoxapentadecan-1-azide; S-Acetyl-PEG3-azide; Azido-PEG3-S-acetyl; 3,6,9-Trioxa-12-thiapentadecan-15-oic acid, 1-azido-, 15-acetyl-12-thio-; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl ethanethioate; Acetyl-PEG3-N3; N3-PEG3-SAc
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg3-Azido is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support cGMP-grade production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.