Description

Methyl cis-4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylate is a high-purity, protected amino acid derivative and a crucial chiral building block in organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and advanced materials. Pharmaceutical R&D teams, agrochemical manufacturers, and specialty chemical producers need it for synthesizing peptides, peptidomimetics, and other bioactive compounds where controlled stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Agrochemical Research: Used in the synthesis of chiral active ingredients for crop protection products, where specific stereoisomers often exhibit enhanced biological activity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and protein interactions.
• Material Science: Acts as a monomer or precursor for functionalized polymers and advanced materials requiring specific chiral centers.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and catalysis studies.

Basic Information

Product Name	Methyl cis-4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylate
CAS No.	1310708-60-1
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	Methyl (3R,4S)-4-[(tert-Butoxycarbonyl)amino]tetrahydrofuran-3-carboxylate; Methyl cis-4-(Boc-amino)tetrahydrofuran-3-carboxylate; (3R,4S)-4-((tert-Butoxycarbonyl)amino)tetrahydrofuran-3-carboxylic acid methyl ester; Boc-4-amino-tetrahydrofuran-3-carboxylic acid methyl ester (cis); cis-4-(Boc-amino)oxolane-3-carboxylic acid methyl ester; 1310708-60-1; Boc-Aze-OH(OMe) (related to azetidine derivatives)
EINECS	Contact for details

Quality Control

Our Methyl cis-4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (cis isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.