Description

Ethyl 4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate is a high-value, protected pyrrolopyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the precise construction of complex heterocyclic scaffolds, which are fundamental to modern drug discovery programs. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on kinase inhibitors and other biologically active small molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular tools to study biological pathways and protein function.
• Material Science Research: A potential monomer or precursor for advanced organic electronic materials due to its fused heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring complex, protected intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organosilicon chemistry.

Basic Information

Item	Details
Product Name	Ethyl 4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate
CAS No.	1310704-15-4
Molecular Formula	C19H29ClN2O2Si
Molecular Weight	380.99 g/mol
Synonyms	4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid ethyl ester; Ethyl 4-chloro-1-[(triisopropylsilyl)]-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 4-chloro-1-(triisopropylsilyl)-, ethyl ester; TIPS-protected 4-chloropyrrolopyridine ester; 4-Chloro-1-TIPS-1H-pyrrolo[2,3-b]pyridine-5-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ICH guidelines ensure the material meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.