Description

5-(2-Hydroxypropan-2-Yl)Pyridin-3-Ylboronic Acid CAS NO 1310404-56-8 is a high-purity boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex pyridine-based heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-boronic acid coupling steps.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, via cross-coupling polymerization.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and protein interactions.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Item	Information
Product Name	5-(2-Hydroxypropan-2-Yl)Pyridin-3-Ylboronic Acid
CAS No.	1310404-56-8
Molecular Formula	C8H12BNO3
Molecular Weight	180.99 g/mol
Synonyms	5-(2-Hydroxy-2-propyl)pyridine-3-boronic acid; 3-Pyridineboronic acid, 5-(2-hydroxy-2-propyl)-; 5-(2-Hydroxypropan-2-yl)-3-pyridinylboronic acid; 5-(1-Hydroxy-1-methylethyl)pyridin-3-ylboronic acid; 5-(2-Hydroxy-2-propyl)-3-pyridinylboronic acid; Boronic acid, B-[5-(2-hydroxy-2-propyl)-3-pyridinyl]-; 5-(2-Hydroxypropan-2-yl)pyridine-3-boronic acid
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Hydroxypropan-2-Yl)Pyridin-3-Ylboronic Acid undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC, NMR, and IR is provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.