Description

6-(Cyclobutoxy)Pyridine-2-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient formation of carbon-carbon bonds. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for constructing complex molecular architectures. Its stability as a pinacol ester makes it a reliable reagent for demanding synthesis workflows.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates containing biaryl or heterobiaryl motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Employed in the creation of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Synthesis: Serves as a versatile coupling partner in palladium-catalyzed Suzuki-Miyaura reactions for academic and industrial research.
• Ligand Synthesis: Useful for preparing complex ligands used in catalysis and coordination chemistry.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	6-(Cyclobutoxy)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310404-15-9
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	2-(6-Cyclobutoxypyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Cyclobutoxy-2-pyridineboronic acid pinacol ester; 2-(6-Cyclobutoxypyridin-2-yl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; 6-Cyclobutoxypyridine-2-boronic acid pinacol ester; 2-(6-Cyclobutoxy-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-[6-(Cyclobutoxy)-2-pyridinyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 6-(Cyclobutoxy)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.