Description

Boc-3-Amino-4-Methylpyridine-2-Boronic Acid Pinacol Ester CAS NO 1310385-05-7 is a high-value, protected boronic acid ester derivative, serving as a critical advanced pharmaceutical intermediate for modern drug discovery. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine cores.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the pyridine ring and various aryl/heteroaryl halides or triflates under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical space for kinase inhibitors, antiviral agents, and other therapeutic targets.
• Agrochemical Research: Intermediate in the synthesis of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science Precursor: Potential building block for creating organic electronic materials, ligands for catalysts, or metal-organic frameworks (MOFs).
• Process Chemistry & Scale-up: Suitable for development from milligram-scale research to multi-kilogram GMP production for clinical trial material supply.

Basic Information

Product Name	Boc-3-Amino-4-Methylpyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310385-05-7
Molecular Formula	C18H27BN2O4
Molecular Weight	346.23 g/mol
Synonyms	2-[(3-Amino-4-methyl-2-pyridinyl)boronic acid] pinacol ester, N-Boc protected; tert-Butyl (4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate; 3-[(tert-Butoxycarbonyl)amino]-4-methylpyridine-2-boronic acid pinacol ester; Boc-3-Amino-4-Methyl-2-pyridineboronic Acid Pinacol Ester; N-Boc-3-Amino-4-methylpyridine-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-[(tert-butoxycarbonyl)amino]-4-methylpyridine
EINECS	Contact for details

Quality Control

Our Boc-3-Amino-4-Methylpyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity (by HPLC/NMR), identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.