Description

4-(tert-Butoxycarbonyl)Pyridine-2-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound matters as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by pharmaceutical R&D and fine chemical synthesis laboratories for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly in constructing pyridine-containing heterocycles prevalent in kinase inhibitors and other therapeutic agents.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for palladium-catalyzed carbon-carbon bond formation with aryl or vinyl halides.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: A precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems.

Basic Information

Item	Details
Product Name	4-(tert-Butoxycarbonyl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310385-01-3
Molecular Formula	C₁₇H₂₄BNO₄
Molecular Weight	317.19 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-[(tert-butoxy)carbonyl]pyridine; 4-(Boc)pyridine-2-boronic acid pinacol ester; 4-(tert-Butoxycarbonyl)-2-pyridineboronic acid pinacol ester; 2-Borono-4-(tert-butoxycarbonyl)pyridine pinacol ester; 4-Boc-2-pyridylboronic acid pinacol ester; tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinate; CAS 1310385-01-3
EINECS	Contact for details

Quality Control

Every batch of 4-(tert-Butoxycarbonyl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis by HPLC, NMR (¹H and ¹³C), and other relevant spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.