Description

6-(Di-Boc-Amino)Pyridine-2-Boronic Acid Pinacol Ester is a high-purity, protected boronic ester building block designed for advanced organic synthesis. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries to create novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex pyridine-containing scaffolds in drug discovery and development programs.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between the pyridine ring and various aryl or heteroaryl halides under palladium catalysis.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection products.
• Material Science: Serves as a precursor for creating functionalized organic molecules used in electronic materials and ligands for catalysis.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the synthesis of bifunctional molecules for targeted protein degradation studies.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	6-(Di-Boc-Amino)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310384-87-2
Molecular Formula	C21H31BN2O6
Molecular Weight	418.29 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-1-carboxylic acid tert-butyl ester; 6-(Bis(tert-butoxycarbonyl)amino)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-(Di-tert-butoxycarbonylamino)pyridine-2-boronic acid pinacol ester; 2-(Di-Boc-amino)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-(N,N-Di-Boc-amino)pyridine-2-boronic acid pinacol ester; 6-(Di-Boc-amino)-2-pyridineboronic acid pinacol ester; 2-Borono-6-(di-Boc-amino)pyridine pinacol ester.
EINECS	Contact for details

Quality Control

Our 6-(Di-Boc-Amino)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.