Description

5-Hydroxypyridine-2-Boronic Acid Pinacol Ester is a versatile and high-purity boronic ester derivative, essential for modern synthetic chemistry. Its primary value lies in its role as a key building block in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is critically needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct novel heterocyclic scaffolds for next-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate ligands for transition metal catalysis, enhancing reaction selectivity and yield.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Library Synthesis for Drug Discovery: A valuable building block in parallel and combinatorial chemistry for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Hydroxypyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310383-01-7
Molecular Formula	C11H16BNO3
Molecular Weight	221.06 g/mol
Synonyms	5-Hydroxy-2-pyridineboronic acid pinacol ester; 2-(5-Hydroxypyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Hydroxypyridine-2-boronic acid neopentyl glycol ester (common alternative); 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-5-ol; 5-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; PINACOL (5-HYDROXYPYRIDIN-2-YL)BORONATE
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxypyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets high-purity research specifications, with comprehensive identity and purity verification via NMR, HPLC, and LC-MS. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.