Description

(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-1-Butanol is a high-purity, chiral synthetic intermediate featuring a tert-butyldiphenylsilyl (TBDPS) protecting group. This compound is critical for enabling complex, stereoselective synthesis in advanced pharmaceutical research and development. It is primarily utilized by process chemists and R&D teams in the pharmaceutical, agrochemical, and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and other high-value chiral molecules.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the stereocontrolled construction of complex drug molecules, particularly in oncology and antiviral research.
• Asymmetric Synthesis: Used in reactions requiring high enantiomeric purity, such as asymmetric aldol reactions and nucleophilic additions.
• Protecting Group Chemistry: The TBDPS group provides robust protection for secondary alcohols under a wide range of reaction conditions, allowing for selective deprotection in multi-step syntheses.
• Process Chemistry & Scale-up: Serves as a reliable intermediate for optimizing and scaling the manufacturing route of target compounds from laboratory to pilot plant scale.
• Agrochemical Active Ingredient Development: Employed in the synthesis of chiral herbicides, fungicides, and pesticides.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and catalysis at universities and research institutes.

Basic Information

Product Name	(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-1-Butanol
CAS No.	1309610-41-0
Molecular Formula	C20H28O2Si
Molecular Weight	328.52 g/mol
Synonyms	(R)-2-((tert-Butyldiphenylsilyl)oxy)butan-1-ol; (2R)-2-[(tert-Butyldiphenylsilyl)oxy]-1-butanol; (R)-1-Butanol, 2-[(1,1-dimethylethyl)diphenylsilyl]oxy]-; TBDPS-protected (R)-1,2-Butanediol derivative; (R)-2-O-TBDPS-1-butanol; tert-Butyldiphenyl((R)-1-hydroxybutan-2-yloxy)silane
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-1-Butanol is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with the high standards required for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.