Description

(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Butanal is a high-purity chiral building block and protected aldehyde intermediate of significant importance in advanced organic synthesis. Its value lies in the tert-butyldiphenylsilyl (TBDPS) protecting group, which offers robust stability under a wide range of reaction conditions while allowing for selective deprotection. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require precise stereochemical control in the synthesis of complex molecules, such as active pharmaceutical ingredients (APIs) and natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly where the (R)-configuration is required.
• Asymmetric Synthesis: Used in stereoselective reactions, including aldol additions and nucleophilic additions to the aldehyde group, to construct molecules with defined chirality.
• Natural Product Synthesis: Serves as a building block in the total synthesis of natural products with intricate stereocenters, leveraging the stability of the TBDPS protecting group.
• Peptidomimetics & Bioactive Molecule Research: Employed in the development of peptide analogs and other bioactive compounds where the protected hydroxy-aldehyde functionality is a crucial structural element.
• Process Chemistry & Scale-up: Suitable for process development from laboratory research to pilot plant and commercial-scale manufacturing due to its defined purity and stability profile.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs serving the global pharmaceutical market.

Basic Information

Product Name	(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Butanal
CAS No.	1309610-38-5
Molecular Formula	C20H26O2Si
Molecular Weight	326.51 g/mol
Synonyms	(R)-2-((tert-Butyldiphenylsilyl)oxy)butanal; (2R)-2-[(tert-Butyldiphenylsilyl)oxy]butyraldehyde; (R)-2-(TBDPS-oxy)butanal; Butanal, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (2R)-; (R)-TBDPS-protected 2-hydroxybutyraldehyde; (R)-2-(tert-Butyldiphenylsiloxy)butanal; (R)-2-O-TBDPS-butanal
EINECS	Contact for details

Quality Control

Our (2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Butanal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with high-purity pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.