Description

Sco - Active Ester (p-Npe) is a specialized active ester derivative, a key building block in advanced organic synthesis. Its primary value lies in its high reactivity, enabling efficient and selective coupling reactions, particularly in peptide synthesis and bioconjugation. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity intermediates for complex molecular assembly.

Application

• Peptide Synthesis: As a carboxyl-activating reagent for the formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: For the site-specific labeling of proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or other functional probes.
• Polymer Chemistry: Used in the synthesis of functionalized polymers and dendrimers requiring precise control over end-group chemistry.
• Prodrug Development: Employed to create hydrolyzable ester linkages for controlled drug release and improved pharmacokinetics.
• Chemical Biology: A critical tool for creating chemical probes to study enzyme function and protein-protein interactions.
• Material Science: For surface modification and the covalent attachment of organic molecules to inorganic substrates.

Basic Information

Item	Detail
Product Name	Sco - Active Ester (p-Npe)
CAS No.	1309581-51-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	p-Nitrophenyl Ester of Sco; Sco p-Nitrophenyl Ester; Active Ester p-Npe; 1309581-51-8; Sco-O-pNP; p-Nitrophenyl SCO ester; Npe ester of Sco acid
EINECS	Contact for details

Quality Control

Our Sco - Active Ester (p-Npe) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.