Description

3-Nitro-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected pyrrolidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing pyrrolidine or proline scaffolds.
• Protease Inhibitor Research: Used in the development of inhibitors targeting various proteases due to its nitro-pyrrolidine structure.
• Peptidomimetics & Constrained Peptides: Serves as a backbone-constrained amino acid analog for creating stable peptide mimics with enhanced pharmacological properties.
• Agrochemical Synthesis: Employed as an intermediate in the creation of novel herbicides, fungicides, and insecticides.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Material Science Research: Acts as a precursor for functionalized polymers or ligands in catalyst systems.

Basic Information

Product Name	3-Nitro-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1309581-43-8
Molecular Formula	C9H16N2O4
Molecular Weight	216.24 g/mol
Synonyms	tert-Butyl 3-nitropyrrolidine-1-carboxylate; 1-Boc-3-nitropyrrolidine; 3-Nitro-1-Boc-pyrrolidine; 1-(tert-Butoxycarbonyl)-3-nitropyrrolidine; Pyrrolidine-1-carboxylic acid, 3-nitro-, 1,1-dimethylethyl ester; Boc-3-Nitro-pyrrolidine; 3-Nitropyrrolidine-1-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 3-nitropyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Nitro-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.