Description

Acid-Peg5-Mono-Methyl Ester CAS NO 1309460-30-7 is a high-purity, functionalized polyethylene glycol (PEG) derivative, specifically a monomethyl ether terminated with a carboxylic acid group. This bifunctional structure is critical for creating stable, water-soluble conjugates and linkages in advanced chemical synthesis. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and material science sectors who require precise and reliable PEGylation reagents.

Application

• Pharmaceutical PEGylation: A key reagent for modifying therapeutic proteins, peptides, and oligonucleotides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Bioconjugation & Linker Chemistry: Used to create cleavable or stable linkages between drugs, targeting ligands, and diagnostic labels via its reactive acid and PEG spacer.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for synthesizing hydrogels, smart polymers, and surface coatings with tailored hydrophilicity and biofunctionality.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents, fluorescent probes, and assay components where water solubility and biocompatibility are paramount.
• Nanoparticle Functionalization: Used to modify the surface of liposomes, dendrimers, and other nanocarriers to improve stealth properties and enable targeted delivery.
• Chemical Intermediate: Acts as a versatile precursor for further derivatization to create esters, amides, and other specialized PEG derivatives.

Basic Information

Product Name	Acid-Peg5-Mono-Methyl Ester
CAS No.	1309460-30-7
Molecular Formula	C17H34O9
Molecular Weight	382.45 g/mol
Synonyms	mPEG5-acid; 5-(Methoxy)-3,6,9,12,15-pentaoxaheptadecanoic acid; Methoxy-PEG5-propionic acid; α-Methyl-ω-carboxypentadecaethylene glycol; mPEG(5) CH2CH2COOH; Carboxy-PEG5-OMe; HOOC-PEG5-OCH3; PEG linker acid, MW 382
EINECS	Contact for details

Quality Control

Our Acid-Peg5-Mono-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Acid Value (Titration)	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.