Description

Acid-Peg5-T-Butyl Ester is a specialized polyethylene glycol (PEG)-based ester derivative, a key intermediate in advanced organic synthesis and bioconjugation. Its value lies in providing a protected carboxylic acid functionality linked to a hydrophilic PEG spacer, enabling precise modification of molecules to enhance solubility, stability, and pharmacokinetic properties. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity building blocks for drug discovery, peptide synthesis, and polymer chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutics.
• Bioconjugation & Linker Chemistry: Used to attach drugs, dyes, or other functional groups to proteins, peptides, or nanoparticles via its reactive ester group.
• Polymer & Material Science: Serves as a monomer or modifier for creating functionalized, biocompatible PEG-based polymers and hydrogels.
• Peptide Synthesis: Employed as a protecting group or as a solubilizing tag during solid-phase peptide synthesis (SPPS).
• Surface Functionalization: Used to modify surfaces with PEG chains to create non-fouling, hydrophilic coatings for medical devices and biosensors.
• Research & Development: A valuable tool compound in chemical biology and medicinal chemistry research for exploring structure-activity relationships.

Basic Information

Product Name	Acid-Peg5-T-Butyl Ester
CAS No.	1309460-29-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	t-Butyl-PEG5-acid; 2,5,8,11,14-Pentaoxaheptadecanedioic acid, 17-(1,1-dimethylethyl) ester; tert-Butyl-PEG5-propionic acid; 3,6,9,12,15-Pentaoxaoctadecanoic acid, 18-tert-butyl ester; PEG5-t-butyl ester acid; Acid-terminated PEG5 t-butyl ester; tert-Butyl-O-PEG5-acid; (PEG)5-t-butyl ester carboxylic acid
EINECS	Contact for details

Quality Control

Our Acid-Peg5-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.