Description

2-Methoxy-6-Methylpyridin-4-Ylboronic Acid is a specialized organoboron compound belonging to the pyridine-boronic acid class, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in creating complex heterocyclic cores for drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its boronic acid functionality for structure diversification.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: A fundamental reagent for palladium-catalyzed carbon-carbon bond formation, critical for assembling conjugated systems and complex molecular architectures.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and labeled compounds for biochemical and diagnostic applications.
• Catalyst & Ligand Preparation: Serves as a precursor for synthesizing novel catalysts and chiral ligands used in asymmetric synthesis.

Basic Information

Product Name	2-Methoxy-6-Methylpyridin-4-Ylboronic Acid
CAS No.	1309443-98-8
Molecular Formula	C8H12BNO3
Molecular Weight	181.00 g/mol
Synonyms	(2-Methoxy-6-methylpyridin-4-yl)boronic acid; 4-Borono-2-methoxy-6-methylpyridine; 2-Methoxy-6-methyl-4-pyridineboronic acid; 6-Methyl-2-methoxypyridine-4-boronic acid; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxy-6-methylpyridine (protected form); 2-Methoxy-6-methylpyridine-4-boronic acid; 2-Methoxy-6-methyl-4-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Methoxy-6-Methylpyridin-4-Ylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.