Description

tert-Butyl 3-(N'-Hydroxycarbamimidoyl)-Azetidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected azetidine ring and a key amidoxime functional group. This compound is critical for medicinal chemists as a versatile building block in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition. It is primarily utilized in research and development for the production of innovative therapeutic agents within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates, particularly those containing the azetidine pharmacophore.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific enzymes involved in disease pathways.
• Bioconjugation & Probe Synthesis: The reactive amidoxime group can be utilized for the creation of chemical probes or for bioconjugation strategies in drug discovery.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex target molecules for clients.

Basic Information

Product Name	tert-Butyl 3-(N'-Hydroxycarbamimidoyl)-Azetidine-1-Carboxylate
CAS No.	1309207-05-3
Molecular Formula	C9H17N3O3
Molecular Weight	215.25 g/mol
Synonyms	1-Boc-3-amidinoamidoxime-azetidine; 1-(tert-Butoxycarbonyl)-3-(N'-hydroxycarbamimidoyl)azetidine; 3-(N'-Hydroxycarbamimidoyl)azetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(amidinoamidoxime)azetidine-1-carboxylate; Azetidine-1-carboxylic acid, 3-(N'-hydroxycarbamimidoyl)-, 1,1-dimethylethyl ester; 1309207-05-3; Boc-3-amidinoamidoxime-azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(N'-Hydroxycarbamimidoyl)-Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.