Description

R-Ozanimod is a high-purity, small molecule pharmaceutical intermediate and reference standard of significant importance in modern drug development. Its primary value lies in its role as a key chiral building block for the synthesis of Ozanimod, a sphingosine-1-phosphate (S1P) receptor modulator used in the treatment of autoimmune diseases. This compound is essential for research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in the synthesis, process optimization, and analytical verification of advanced therapeutic agents targeting multiple sclerosis and ulcerative colitis.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the multi-step synthesis of the active pharmaceutical ingredient (API) Ozanimod.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (HPLC, LC-MS) to ensure the identity, purity, and potency of final drug substances.
• Process Chemistry Research: Serves as a key material for investigating and scaling up novel, efficient synthetic routes in process R&D.
• Regulatory Submission: Provides essential chemical entity data and samples for regulatory filings (e.g., FDA, EMA) supporting drug approval dossiers.
• Impurity Profiling: Utilized as a marker to identify, quantify, and control related substances and potential genotoxic impurities during API manufacturing.
• Academic & Biomedical Research: Supports fundamental research into S1P receptor biology and the development of next-generation immunomodulatory therapies.

Basic Information

Product Name	R-Ozanimod
CAS No.	1306760-86-0
Molecular Formula	C23H29FN4O2
Molecular Weight	412.50 g/mol
Synonyms	(R)-Ozanimod; (R)-CC-11244; UNII-6Q1G4QK3Q0; (R)-4-((3S,4R)-3-Ethyl-4-((3-fluorophenyl)ethynyl)piperidin-1-yl)butylcarbamimidoyl cyanide; (R)-4-[(3S,4R)-3-Ethyl-4-(3-fluorophenylethynyl)-1-piperidinyl]butylcarbamimidoyl cyanide; CC-11244 (R-enantiomer); R-Enantiomer of Ozanimod; BMS-911145 Impurity
EINECS	Contact for details

Quality Control

Our R-Ozanimod CAS NO 1306760-86-0 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical development. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines, supporting our clients' needs for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.