Description

Aminoxy-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an aminoxy group and an azide terminus. This compound is engineered for efficient and selective bioconjugation, enabling the stable linkage of biomolecules under mild, aqueous conditions. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, where precise and stable molecular assembly is required.

Application

• Bioconjugation and Protein Labeling: Used for site-specific modification of proteins, antibodies, and peptides via oxime ligation with ketone or aldehyde groups.
• ADC (Antibody-Drug Conjugate) Development: Serves as a versatile linker for constructing stable ADCs by connecting cytotoxic payloads to antibodies.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and microarray surfaces with biomolecules for diagnostic and research applications.
• Click Chemistry: The azide terminus allows for subsequent copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, enabling multi-step, orthogonal conjugation strategies.
• Polymer and Hydrogel Synthesis: Acts as a functional crosslinker in the creation of smart biomaterials and hydrogels with tailored biological properties.
• Diagnostic Reagent Formulation: Utilized in the development of immunoassays and molecular probes for enhanced detection sensitivity and specificity.

Basic Information

Product Name	Aminoxy-Peg3-Azide
CAS No.	1306615-51-9
Molecular Formula	C11H22N4O5
Molecular Weight	290.32 g/mol
Synonyms	3-Azidopropyl-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]amine; O-(2-Aminoethyl)-O'-(3-azidopropyl)triethylene glycol; Aminoxy-PEG3-azide; Azido-PEG3-aminoxy; N-(3-Azidopropyl)-O-[2-[2-(2-aminoethoxy)ethoxy]ethyl]hydroxylamine; 3-Azido-1-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propylamine; PEG-based aminoxy-azide crosslinker
EINECS	Contact for details

Quality Control

Our Aminoxy-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. Allow the vial to warm to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.