Description

tert-Butyl (5-Chloro-1H-Pyrrolo-[2,3-B]Pyridin-6-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrrolopyridine scaffold. This compound is of critical importance for medicinal chemistry research and development, serving as a key building block in the synthesis of targeted therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel small-molecule drugs, particularly kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Kinase Inhibitor Development: Serves as a core scaffold for the research and synthesis of novel kinase inhibitors due to the privileged pyrrolopyridine structure.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Bioconjugation & Probe Synthesis: The carbamate protecting group and reactive chlorine atom allow for further functionalization, making it suitable for creating chemical probes or antibody-drug conjugate (ADC) linkers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development projects for global pharmaceutical companies.

Basic Information

Product Name	tert-Butyl (5-Chloro-1H-Pyrrolo-[2,3-B]Pyridin-6-Yl)Carbamate
CAS No.	1305325-11-4
Molecular Formula	C12H14ClN3O2
Molecular Weight	267.71 g/mol
Synonyms	5-Chloro-6-(((tert-butoxy)carbonyl)amino)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 5-chloro-, 1,1-dimethylethyl ester; 5-Chloro-1H-pyrrolo[2,3-b]pyridin-6-yl carbamic acid tert-butyl ester; tert-Butyl N-(5-chloro-1H-pyrrolo[2,3-b]pyridin-6-yl)carbamate; BOC-5-Chloro-6-amino-1H-pyrrolo[2,3-b]pyridine; 1305325-11-4; 5-Chloro-6-Boc-amino-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Chloro-1H-Pyrrolo-[2,3-B]Pyridin-6-Yl)Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each shipment to guarantee traceability and consistency for your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.