Description

5-Bromo-3-Iodo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a highly functionalized, multi-halogenated pyrrolopyridine derivative designed for advanced synthetic chemistry. This compound is a critical high-purity building block for medicinal chemistry and materials science research, offering multiple reactive sites for selective cross-coupling and functional group transformations. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) engaged in the development of novel small-molecule therapeutics and functional organic materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis due to its versatile bromo and iodo substituents for palladium-catalyzed couplings.
• Agrochemical Development: Employed in the research phase for creating novel active ingredients with specific biological activity.
• Organic Electronic Materials: Acts as a functionalized core unit for constructing π-conjugated systems used in OLEDs or organic semiconductors.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and target engagement.
• Custom Synthesis & Scale-Up: A valuable starting material for custom synthesis houses offering contract manufacturing services from milligram to kilogram scale.

Basic Information

Product Name	5-Bromo-3-Iodo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1305325-04-5
Molecular Formula	C18H18BrIN2O2SSi
Molecular Weight	561.22 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-(phenylsulfonyl)-2-(trimethylsilyl)-; 5-Bromo-3-iodo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 2-(Trimethylsilyl)-5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1305325-04-5; TMS-protected bromo-iodo pyrrolopyridine sulfonamide
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.