Description

4-Chloro-5-Fluoro-3-Iodo-1H-Pyrrolo-[2,3-B]Pyridine-6-Carbaldehyde is a highly functionalized, multi-halogenated heterocyclic building block of significant synthetic value. This compound matters as a key advanced intermediate for constructing complex molecular architectures, particularly in pharmaceutical discovery and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Agrochemical Research: Used to develop novel active ingredients with specific biological activity for crop protection.
• Chemical Biology Probes: Serves as a versatile scaffold for creating molecular probes to study biological pathways and protein function.
• Material Science: Potential building block for organic electronic materials and metal-organic frameworks (MOFs) due to its halogenated, electron-deficient structure.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by allowing derivatization at multiple reactive sites (aldehyde, halogens).
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig cross-coupling reactions.

Basic Information

Product Name	4-Chloro-5-Fluoro-3-Iodo-1H-Pyrrolo-[2,3-B]Pyridine-6-Carbaldehyde
CAS No.	1305324-96-2
Molecular Formula	C8H3ClFINO
Molecular Weight	325.47 g/mol
Synonyms	4-Chloro-5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine-6-carboxaldehyde; 1H-Pyrrolo[2,3-b]pyridine-6-carboxaldehyde, 4-chloro-5-fluoro-3-iodo-; 1305324-96-2; 4-Chloro-5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine-6-carbaldehyde; 4-Chloro-5-fluoro-3-iodo-7-azaindole-6-carbaldehyde
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For this advanced intermediate, quality is assured through comprehensive analytical methods including HPLC, NMR, and LC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to cGMP principles for the manufacture of pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.