Description

5-Bromo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to provide a versatile scaffold for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is an essential intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific bromo, sulfonyl, and silyl-protected functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its unique pyrrolopyridine core.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi).
• Functional Group Manipulation: The trimethylsilyl group acts as a protective group or a directing group for further regioselective functionalization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1305324-90-6
Molecular Formula	C18H19BrN2O2SSi
Molecular Weight	435.42 g/mol
Synonyms	5-Bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-; 1305324-90-6; 5-Bromo-2-(trimethylsilyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 2-(Trimethylsilyl)-5-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Phenylsulfonyl)-2-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.