Description

5-Chloro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 1305324-71-3 is a high-value, multi-functionalized pyrrolopyridine derivative designed for advanced synthetic chemistry. This compound serves as a critical key intermediate and building block in the development of complex organic molecules, particularly in pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A versatile building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its halogenated and silyl-protected structure for targeted activity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its fused heterocyclic core.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki-Miyaura and Negishi cross-coupling reactions to introduce complex aryl and alkyl groups.
• Protecting Group Strategy: The triisopropylsilyl (TIPS) and trimethylsilyl (TMS) groups can be used strategically in multi-step synthesis for selective deprotection and functionalization.
• Ligand Synthesis: Potential precursor for the development of novel nitrogen-containing ligands for catalysis.

Basic Information

Item	Details
Product Name	5-Chloro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1305324-71-3
Molecular Formula	C21H36ClIN2Si2
Molecular Weight	543.52 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-chloro-6-iodo-1-(triisopropylsilyl)-4-(trimethylsilyl)-; 5-Chloro-6-iodo-1-(triisopropylsilyl)-4-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS/TMS-protected pyrrolopyridine; Halogenated pyrrolopyridine silyl ether; Advanced pharmaceutical intermediate (API intermediate); Building block for heterocyclic synthesis
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance in sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.