Description

3-Bromo-5-Iodo-1H-Pyrazolo[3,4-B]Pyridine is a high-value, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which allows for precise functionalization and the construction of complex nitrogen-containing structures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to build complex heterocyclic cores for new pesticides and herbicides with improved efficacy.
• Material Science: Serves as a building block for creating specialized organic electronic materials and ligands for catalysis.
• Chemical Biology: Employed in the development of molecular probes and tool compounds for biological target validation.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for versatile palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	3-Bromo-5-Iodo-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1305324-61-1
Molecular Formula	C6H3BrIN3
Molecular Weight	323.92 g/mol
Synonyms	3-Bromo-5-iodo-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-iodo-; 1305324-61-1; 3-Br-5-I-1H-pyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridine, 3-bromo-5-iodo-
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Iodo-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.