Description

2-Bromo-5-Methoxypyridine 1-Oxide is a versatile and high-value heterocyclic building block used in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials due to its reactive bromine and N-oxide functionalities. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its pyridine core for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Functional Group Manipulation: The N-oxide group can be utilized for directed ortho-lithiation or as a leaving group for further functionalization.

Basic Information

Product Name	2-Bromo-5-Methoxypyridine 1-Oxide
CAS No.	1305322-98-8
Molecular Formula	C6H6BrNO2
Molecular Weight	204.02 g/mol
Synonyms	5-Methoxy-2-bromopyridine 1-Oxide; 2-Bromo-5-methoxypyridine N-Oxide; 2-Bromo-5-methoxypyridine Oxide; Pyridine, 2-bromo-5-methoxy-, 1-oxide; 1305322-98-8
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Methoxypyridine 1-Oxide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.