Description

1-(5-Fluoropyridin-3-Ylsulfonyl)-n-Methylpiperidin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-linked heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Protease Inhibitor Development: Serves as a core scaffold or side-chain component in the design of protease inhibitors due to its sulfonamide moiety.
• Kinase Inhibitor Synthesis: Employed in the construction of molecules designed to modulate kinase activity, relevant in cancer and inflammatory disease research.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up under cGMP conditions for clinical trial material production.

Basic Information

Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)-n-Methylpiperidin-4-Amine
CAS No.	1305257-87-7
Molecular Formula	C11H16FN3O2S
Molecular Weight	273.33 g/mol
Synonyms	N-Methyl-1-[(5-fluoropyridin-3-yl)sulfonyl]piperidin-4-amine; 4-Amino-N-methyl-1-(5-fluoropyridine-3-sulfonyl)piperidine; 1-[(5-Fluoropyridin-3-yl)sulfonyl]-N-methylpiperidin-4-amine; 4-(Methylamino)-1-(5-fluoropyridine-3-sulfonyl)piperidine; 1305257-87-7; 5-Fluoro-3-[(4-(methylamino)piperidin-1-yl)sulfonyl]pyridine
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoropyridin-3-Ylsulfonyl)-n-Methylpiperidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development from milligram to kilogram scale with consistent quality, and can work towards specific customer protocols or impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.