Description

2-Bromo-5-Fluoropyridine-3-Carbonitrile is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and nitrile substituents, makes it an exceptionally versatile intermediate for constructing complex heterocyclic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced activity.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The fluorine atom can be selectively displaced, allowing for further functionalization of the pyridine core.
• Cyanohydrin & Amide Formation: The nitrile group can be hydrolyzed or reduced to access carboxylic acids, amides, or amines, expanding its utility.

Basic Information

Product Name	2-Bromo-5-Fluoropyridine-3-Carbonitrile
CAS No.	1305208-36-9
Molecular Formula	C6H2BrFN2
Molecular Weight	200.99 g/mol
Synonyms	3-Cyano-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromonicotinonitrile; 2-Bromo-5-fluoro-3-pyridinecarbonitrile; 2-Bromo-5-fluoropyridine-3-carbonitrile; 1305208-36-9; 5-Fluoro-2-bromopyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoropyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.