Description

1,4-Piperidinedicarboxylic Acid, 3,3-Difluoro-, 1-(1,1-Dimethylethyl) 4-Methyl Ester is a high-value, fluorinated piperidine derivative serving as a critical synthetic intermediate. Its core value lies in providing a protected, functionalized scaffold essential for constructing complex molecules in advanced research and development. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially protease inhibitors and enzyme modulators.
• Agrochemical Research: Used in developing novel herbicides and pesticides with enhanced activity and selectivity.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating fluorinated probes to study enzyme mechanisms and protein interactions.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with unique thermal or chemical resistance properties.
• Organic Synthesis Scaffold: Utilized in medicinal chemistry for parallel synthesis and library development due to its reactive ester and protected amine groups.

Basic Information

Product Name	1,4-Piperidinedicarboxylic Acid, 3,3-Difluoro-, 1-(1,1-Dimethylethyl) 4-Methyl Ester
CAS No.	1303973-86-5
Molecular Formula	C13H21F2NO4
Molecular Weight	293.31 g/mol
Synonyms	tert-Butyl 3,3-difluoro-4-(methoxycarbonyl)piperidine-1-carboxylate; 1-Boc-3,3-difluoro-4-piperidinecarboxylic Acid Methyl Ester; 3,3-Difluoro-1-Boc-piperidine-4-carboxylic Acid Methyl Ester; Methyl 1-(tert-butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylate; 1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic Acid Methyl Ester; 3,3-Difluoro-N-Boc-isonipecotic Acid Methyl Ester; 3,3-Difluoro-1-Boc-4-piperidinecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 1,4-Piperidinedicarboxylic Acid, 3,3-Difluoro-, 1-(1,1-Dimethylethyl) 4-Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.