Description

tert-Butyl1-Isopropyl-1,4-Dihydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate is a sophisticated spirocyclic organic compound that serves as a critical building block in modern pharmaceutical research and development. Its unique molecular architecture, featuring fused indazole and piperidine rings, makes it a valuable intermediate for constructing complex bioactive molecules. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Discovery: Employed in the synthesis of potential therapeutics targeting neurological disorders due to its spirocyclic, nitrogen-rich heterocyclic core.
• Oncology Research: Serves as a building block for novel small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Used for scaling up synthetic routes during the transition from laboratory research to pilot-scale manufacturing.

Basic Information

Product Name	tert-Butyl1-Isopropyl-1,4-Dihydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate
CAS No.	1301214-80-1
Molecular Formula	C19H27N3O2
Molecular Weight	329.44 g/mol
Synonyms	1'-Boc-1-isopropyl-1,4-dihydrospiro[indazole-5,4'-piperidine]; tert-Butyl 1-isopropyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate; 1,4-Dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylic acid, 1-(1-methylethyl)-, 1,1-dimethylethyl ester; 1-Isopropyl-1,4-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indazole-5,4'-piperidine]-1'-carboxylic acid, 1,4-dihydro-1-(1-methylethyl)-, 1,1-dimethylethyl ester; 1301214-80-1; Boc-protected spirocyclic indazole-piperidine intermediate.
EINECS	Contact for details

Quality Control

Our tert-Butyl1-Isopropyl-1,4-Dihydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.