Description

tert-Butyl (E)-10-((Dimethylamino)Methylene)-9-Oxo-3-Azaspiro[5.5]Undec-7-Ene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and enone structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: A key building block in the production route for potential therapeutic agents targeting specific biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and synthesizing complex molecular architectures.

Basic Information

Product Name	tert-Butyl (E)-10-((Dimethylamino)Methylene)-9-Oxo-3-Azaspiro[5.5]Undec-7-Ene-3-Carboxylate
CAS No.	1301214-79-8
Molecular Formula	C18H28N2O3
Molecular Weight	320.43 g/mol
Synonyms	tert-Butyl 10-[(E)-(dimethylamino)methylene]-9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate; 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 10-[(E)-(dimethylamino)methylene]-9-oxo-, 1,1-dimethylethyl ester; (E)-tert-Butyl 10-((dimethylamino)methylene)-9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate; CAS 1301214-79-8; Spirocyclic enaminone intermediate; tert-Butyl ester spiro intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with higher grades available. Certificates of Analysis (COA) detailing identity (IR, NMR), purity (HPLC), and related substance profiles are provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.