Description

3-Bromo-5-Nitropyridin-4-Yl Trifluoromethanesulfonate CAS NO 1299607-67-2 is a high-value, multi-functional chemical intermediate featuring both a bromo and a nitro substituent on a pyridine core, activated by a triflate leaving group. This unique structure makes it a critical building block for the synthesis of complex heterocyclic compounds, enabling rapid molecular diversification in drug discovery and advanced material science. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides due to its reactive halogen and nitro functional groups.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and photoactive materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The triflate group is a superior leaving group, facilitating efficient nucleophilic aromatic substitution (SNAr) reactions.
• Chemical Library Synthesis: Employed in parallel and combinatorial chemistry for high-throughput screening and hit-to-lead optimization.

Basic Information

Item	Detail
Product Name	3-Bromo-5-Nitropyridin-4-Yl Trifluoromethanesulfonate
CAS No.	1299607-67-2
Molecular Formula	C7H2BrF3N2O5S
Molecular Weight	354.06 g/mol
Synonyms	3-Bromo-5-nitropyridin-4-yl triflate; 4-Bromo-6-nitro-3-pyridinyl trifluoromethanesulfonate; 3-Bromo-5-nitro-4-pyridyl trifluoromethanesulfonate; 3-Bromo-5-nitropyridin-4-yl trifluoromethanesulphonate; Trifluoromethanesulfonic acid 3-bromo-5-nitro-4-pyridinyl ester; 4-Pyridinol, 3-bromo-5-nitro-, trifluoromethanesulfonate (ester)
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitropyridin-4-Yl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.