Description

1-(7-Bromo-6-(3-((tert-Butyldimethylsilyl)Oxy)Propyl)-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-1-Yl) is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure with a bromo-substituent and a tert-butyldimethylsilyl (TBDMS) protected alcohol. This compound matters as a critical building block in modern organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with precise molecular architecture. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Organic Synthesis Building Block: Utilized in complex multi-step syntheses, including cross-coupling reactions and functional group transformations, leveraging its reactive bromo and protected hydroxyl groups.
• Process Chemistry: Serves as a standardized starting material for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile scaffold for the introduction of diverse pharmacophores.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of proprietary compounds for clients.
• Academic Research: Used in university and institutional laboratories for methodological development and the study of novel heterocyclic chemistry.

Basic Information

Item	Details
Product Name	1-(7-Bromo-6-(3-((tert-Butyldimethylsilyl)Oxy)Propyl)-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-1-Yl)
CAS No.	1299607-47-8
Molecular Formula	C20H31BrN2O2Si
Molecular Weight	439.47 g/mol
Synonyms	7-Bromo-6-[3-[(tert-butyldimethylsilyl)oxy]propyl]-1,2,3,4-tetrahydro-1,4-oxazino[4,3-a]quinolin-1-one; 1-(7-Bromo-6-(3-((TBDMS)Oxy)Propyl)-2,3-Dihydro-1H-Pyrido[2,3-b][1,4]Oxazin-1-Yl); TBDMS-protected Bromo Pyridoxazinone Intermediate; CAS 1299607-47-8; 1,4-Oxazino[4,3-a]quinolin-1-one derivative; Bromo-substituted silyl ether intermediate
EINECS	Contact for details

Quality Control

Our 1-(7-Bromo-6-(3-((tert-Butyldimethylsilyl)Oxy)Propyl)-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-1-Yl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with ISO standards and supports development under ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.