Description

Ethyl 2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroacetate is a high-purity, specialized organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in pharmaceutical research and material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biphenyl and difluoroacetate motifs for therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the bromo and difluoro functional groups contribute to biological activity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating advanced organic electronic materials and liquid crystal compounds due to its rigid biphenyl core and halogen substituents.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex conjugated systems.
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research focused on introducing and studying the effects of difluoroacetate esters in molecular structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	Ethyl 2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroacetate
CAS No.	1296274-22-0
Molecular Formula	C₁₆H₁₃BrF₂O₂
Molecular Weight	355.18 g/mol
Synonyms	Ethyl 4'-(Bromo)-[1,1'-biphenyl]-4-yl-2,2-difluoroacetate; 2-(4'-Bromobiphenyl-4-yl)-2,2-difluoroacetic Acid Ethyl Ester; 4'-Bromo-4-biphenylyl-2,2-difluoroacetate Ethyl Ester; Ethyl (4'-Bromo[1,1'-biphenyl]-4-yl)difluoroacetate; Difluoro(4'-bromo[1,1'-biphenyl]-4-yl)acetic Acid Ethyl Ester; Biphenyl-4-yl-difluoroacetate Ethyl Ester Bromo Derivative
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material that meets stringent internal standards or compendial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity over time.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.