Description

2-Chloro-5-[2-(Trimethylsilyl)Ethynyl]Pyridin-4-Amine is a high-value, functionalized pyridine derivative featuring both a chloro and a trimethylsilyl-protected ethynyl group. This compound serves as a versatile and critical building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Ligand and Catalyst Development: Employed in the design of novel ligands for transition metal catalysis and organometallic chemistry.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and target engagement.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory synthesis in research laboratories.

Basic Information

Product Name	2-Chloro-5-[2-(Trimethylsilyl)Ethynyl]Pyridin-4-Amine
CAS No.	1296201-72-3
Molecular Formula	C10H15ClN2Si
Molecular Weight	226.78 g/mol
Synonyms	4-Amino-2-chloro-5-[(trimethylsilyl)ethynyl]pyridine; 2-Chloro-5-((trimethylsilyl)ethynyl)pyridin-4-amine; 5-[(Trimethylsilyl)ethynyl]-2-chloro-4-pyridinamine; 2-Chloro-5-(2-trimethylsilylethynyl)pyridin-4-ylamine; 4-Pyridinamine, 2-chloro-5-[(trimethylsilyl)ethynyl]-; TMS-protected 2-chloro-5-ethynylpyridin-4-amine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-[2-(Trimethylsilyl)Ethynyl]Pyridin-4-Amine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.