Description

5-(Toluene-4-Sulfonyloxy)-3,4-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex bioactive molecules. Its core value lies in its role as a versatile building block, enabling the efficient construction of nitrogen-containing heterocycles, which are pivotal in modern drug discovery. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly those focused on developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of piperidine and dihydropyridine derivatives, which are core scaffolds in numerous therapeutic agents.
• API Synthesis: Used in the research and process development of novel Active Pharmaceutical Ingredients (APIs), especially in neurological and cardiovascular drug candidates.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides that require complex heterocyclic structures.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.
• Academic & Industrial R&D: Utilized in academic laboratories and industrial R&D departments for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	5-(Toluene-4-Sulfonyloxy)-3,4-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1293370-51-0
Molecular Formula	C17H23NO5S
Molecular Weight	353.44 g/mol
Synonyms	1-Boc-5-(p-toluenesulfonyloxy)-1,2,3,4-tetrahydropyridine; tert-Butyl 5-[(4-methylphenyl)sulfonyl]oxy]-3,4-dihydro-2H-pyridine-1-carboxylate; 1,2,3,4-Tetrahydro-5-[(p-tolylsulfonyl)oxy]pyridine-1-carboxylic acid tert-butyl ester; 5-(p-Toluenesulfonyloxy)-1,2,3,4-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-Boc-5-OTs-1,2,3,4-tetrahydropyridine; 1-N-Boc-5-(tosyloxy)-1,2,3,4-tetrahydropyridine; Boc-5-OTs-THP
EINECS	Contact for details

Quality Control

Our 5-(Toluene-4-Sulfonyloxy)-3,4-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.