Description

Biotin-PEG6-NH-Boc is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety and a Boc-protected amine. This compound is specifically engineered for the controlled conjugation and labeling of biomolecules, offering precise spacing and enhanced solubility. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation, where reliable and reproducible bioconjugation is critical.

Application

• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies.
• Proteomics & Biomarker Discovery: For biotinylating proteins, peptides, or other molecules for capture on streptavidin/avidin surfaces in pull-down assays and mass spectrometry.
• Diagnostic Reagent Manufacturing: Used in the synthesis of detection probes and labeled antibodies for ELISA, lateral flow assays, and other immunoassays.
• Drug Delivery System Research: Facilitating the construction of targeted nanocarriers and liposomes by providing a functional handle for ligand attachment.
• Surface Functionalization: Modifying chips, beads, or other solid supports with biotin for biosensor and microarray applications.
• Chemical Biology & Tool Compound Synthesis: Creating molecular probes to study protein function, localization, and interaction networks.

Basic Information

Product Name	Biotin-PEG6-NH-Boc
CAS No.	1292268-20-2
Molecular Formula	C34H62N4O11S
Molecular Weight	734.94 g/mol
Synonyms	Biotin-PEG6-amine-Boc; Boc-NH-PEG6-Biotin; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2,2-dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-yl)pentanamide; Biotinamidohexanoic acid PEG6 amine Boc; Biotin-PEG6-t-butyloxycarbonylamine; Biotinylated PEG linker, Boc-protected; PEG6-Biotin-NHBoc
EINECS	Contact for details

Quality Control

Our Biotin-PEG6-NH-Boc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, methanol; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.