Description

n-Boc-2-Thia-6-Azaspiro[3.3]Heptane 2,2-Dioxide is a high-value, protected heterocyclic building block featuring a unique spirocyclic scaffold. This compound is critically important for medicinal chemistry research and development, serving as a versatile intermediate for constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially for targeted therapies.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component due to its rigid, three-dimensional structure.
• Kinase Inhibitor Synthesis: Incorporated into molecules designed to modulate kinase activity for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	n-Boc-2-Thia-6-Azaspiro[3.3]Heptane 2,2-Dioxide
CAS No.	1291487-31-4
Molecular Formula	C10H17NO4S
Molecular Weight	247.31 g/mol
Synonyms	2-Thia-6-azaspiro[3.3]heptane, 2,2-dioxide, 1-(1,1-dimethylethyl) ester; tert-Butyl 2-thia-6-azaspiro[3.3]heptane-2,2-dioxide-6-carboxylate; N-Boc-2-thia-6-azaspiro[3.3]heptane 2,2-dioxide; N-Boc-2-thia-6-azaspiro[3.3]heptane sulfone; 1-Boc-2-thia-6-azaspiro[3.3]heptane 2,2-dioxide; Spirocyclic sulfone Boc-protected amine; Boc-2-Thia-6-Azaspiro[3.3]heptane Sulfone
EINECS	Contact for details

Quality Control

Our n-Boc-2-Thia-6-Azaspiro[3.3]Heptane 2,2-Dioxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.