Description

8-(Piperidin-1-Ylsulfonyl)[1,2,4]-Triazolo[4,3-A]Pyridin-3(2H)-One is a high-purity, advanced pharmaceutical intermediate and research chemical characterized by its fused triazolopyridine core with a piperidine sulfonyl substituent. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique heterocyclic scaffold.
• Biochemical Tool Compound: Serves as a reference standard or probe molecule in enzymatic and receptor binding assays.
• Organic Synthesis: Employed in the development of complex molecules for agrochemical and material science applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for fundamental studies in heterocyclic chemistry and drug discovery.

Basic Information

Product Name	8-(Piperidin-1-Ylsulfonyl)[1,2,4]-Triazolo[4,3-A]Pyridin-3(2H)-One
CAS No.	1291486-82-2
Molecular Formula	C11H14N4O3S
Molecular Weight	282.32 g/mol
Synonyms	8-(Piperidine-1-sulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 8-(1-piperidinylsulfonyl)-; 8-(1-Piperidinylsulfonyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one; 1291486-82-2; 8-(Piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3-ol (tautomer); Triazolopyridine sulfonamide derivative
EINECS	Contact for details

Quality Control

Our 8-(Piperidin-1-Ylsulfonyl)[1,2,4]-Triazolo[4,3-A]Pyridin-3(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic). Keep container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.