Description

1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-3-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-linked piperidine-pyridine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile chemical handle.
• Protease Inhibitor Development: The sulfonamide and amine functional groups make it a valuable scaffold for designing enzyme inhibitors.
• Agrochemical Synthesis: Serves as a building block for developing new active ingredients in crop protection products.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-3-Amine
CAS No.	1291412-08-2
Molecular Formula	C10H14FN3O2S
Molecular Weight	259.30 g/mol
Synonyms	3-Amino-1-[(5-fluoropyridin-3-yl)sulfonyl]piperidine; 1-[(5-Fluoropyridin-3-yl)sulfonyl]piperidin-3-amine; 3-Piperidinamine, 1-[(5-fluoro-3-pyridinyl)sulfonyl]-; 1-(5-Fluoro-3-pyridinesulfonyl)piperidin-3-amine; 1291412-08-2; 5-Fluoro-3-[(3-amino-1-piperidinyl)sulfonyl]pyridine
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-3-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.