Description

cis-7-(Toluene-4-Sulfonyl)-1,3A,4,5,6,7,8,8B-Octahydro-2H-3-Thia-2,7-Diaza-As-Indacene 3,3-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its complex, fused heterocyclic structure incorporating sulfonyl and sulfonamide moieties. This compound is of critical importance for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing new therapeutic agents, especially in areas targeting central nervous system disorders or other complex disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential drug candidates, particularly those with complex polycyclic architectures.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs), especially those containing sulfonamide or bridged heterocyclic systems.
• Chemical Biology Probes: Utilized in the design and synthesis of specialized molecular probes for investigating biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	cis-7-(Toluene-4-Sulfonyl)-1,3A,4,5,6,7,8,8B-Octahydro-2H-3-Thia-2,7-Diaza-As-Indacene 3,3-Dioxide
CAS No.	1290627-07-4
Molecular Formula	C19H22N2O4S2
Molecular Weight	406.52 g/mol
Synonyms	cis-7-(p-Toluenesulfonyl)-1,3a,4,5,6,7,8,8b-octahydro-2H-3-thia-2,7-diaza-as-indacene 3,3-dioxide; 1,3a,4,5,6,7,8,8b-Octahydro-7-[(4-methylphenyl)sulfonyl]-2H-3-thia-2,7-diaza-as-indacene 3,3-dioxide; 7-(Tosyl)-1,3a,4,5,6,7,8,8b-octahydro-2H-3-thia-2,7-diaza-as-indacene 3,3-dioxide; Bridged Sulfonamide Intermediate; Toluene-4-sulfonamide fused heterocycle; CAS 1290627-07-4
EINECS	Contact for details

Quality Control

Our production of cis-7-(Toluene-4-Sulfonyl)-1,3A,4,5,6,7,8,8B-Octahydro-2H-3-Thia-2,7-Diaza-As-Indacene 3,3-Dioxide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards where required, and specifications can be aligned with client-specific pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.