Description

6-Oxo-9-Phenyl-2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel drug candidates, particularly those targeting complex biological pathways. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing advanced molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs) with spirocyclic architectures.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: Potential scaffold for designing inhibitors of specific enzyme families, given its diaza-spiro structure.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study biological targets and pathways.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of complex drug molecules.
• Library Synthesis: A valuable input for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	6-Oxo-9-Phenyl-2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1290627-02-9
Molecular Formula	C18H24N2O3
Molecular Weight	316.40 g/mol
Synonyms	tert-Butyl 6-oxo-9-phenyl-2,7-diazaspiro[4.4]nonane-2-carboxylate; 2,7-Diaza-spiro[4.4]nonane-2-carboxylic acid, 6-oxo-9-phenyl-, 1,1-dimethylethyl ester; 9-Phenyl-2,7-diazaspiro[4.4]nonane-6-one-2-carboxylic acid tert-butyl ester; 1290627-02-9; Spirocyclic diaza compound intermediate; Boc-protected diazaspiro ketone.
EINECS	Contact for details

Quality Control

Our 6-Oxo-9-Phenyl-2,7-Diaza-Spiro[4.4]Nonane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.