Description

Spiro[Piperidine-4,3'-[3H]Pyrrolo[3,2-B]Pyridine]-1-Carboxylic Acid, 1',2'-Dihydro-2'-Oxo-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic heterocyclic compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its complex fused-ring structure makes it a valuable scaffold for medicinal chemistry research, particularly in the development of novel therapeutic agents. This high-purity intermediate is essential for R&D and production teams in the pharmaceutical and biotechnology sectors seeking to develop next-generation drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and high-throughput screening to identify new drug candidates.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and protein function.
• Organic Synthesis: Acts as a versatile precursor for the construction of complex nitrogen-containing heterocycles and spirocyclic compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical development from discovery to commercial scale.

Basic Information

Product Name	Spiro[Piperidine-4,3'-[3H]Pyrrolo[3,2-B]Pyridine]-1-Carboxylic Acid, 1',2'-Dihydro-2'-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1290625-80-7
Molecular Formula	C17H21N3O3
Molecular Weight	315.37 g/mol
Synonyms	tert-Butyl 1',2'-dihydro-2'-oxospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1-carboxylate; 1-(tert-Butoxycarbonyl)-1',2'-dihydro-2'-oxospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]; Spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1-carboxylic acid, 1',2'-dihydro-2'-oxo-, 1,1-dimethylethyl ester; 1290625-80-7; BOC-protected spirocyclic pyrrolopyridine; tert-Butyl 2-oxo-1,2-dihydrospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1-carboxylate
EINECS	Contact for details

Quality Control

Our Spiro[Piperidine-4,3'-[3H]Pyrrolo[3,2-B]Pyridine]-1-Carboxylic Acid, 1',2'-Dihydro-2'-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.