Description

tert-Butyl (3R,4R)-4-Hydroxy-3-Methyl-Piperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds where stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor to ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Agrochemical Research: Serves as a building block for developing new, stereoselective pesticides and herbicides.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and enzyme inhibitors for target validation studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	tert-Butyl (3R,4R)-4-Hydroxy-3-Methyl-Piperidine-1-Carboxylate
CAS No.	1290191-92-2
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	1-Boc-3R,4R-4-Hydroxy-3-methylpiperidine; (3R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-3-methylpiperidine; tert-Butyl (3R,4R)-4-hydroxy-3-methylpiperidine-1-carboxylate; (3R,4R)-4-Hydroxy-3-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-(3R,4R)-4-hydroxy-3-methylpiperidine; BOC-(3R,4R)-4-Hydroxy-3-methylpiperidine; (3R,4R)-4-Hydroxy-3-methylpiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,4R)-4-Hydroxy-3-Methyl-Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.