Description

tert-Butyl (3R,4S)-3-Amino-4-Methylpyrrolidine-1-Carboxylate is a high-purity, stereochemically defined chiral pyrrolidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This advanced pharmaceutical intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Catalysis: Used as a precursor for chiral ligands or organocatalysts in stereoselective synthesis.
• Peptidomimetics & Bioactive Molecule Design: Incorporates the constrained pyrrolidine ring structure into peptide backbones to enhance metabolic stability and receptor binding affinity.
• Agrochemical Research: Serves as a building block for developing novel, stereospecific pesticides and herbicides.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new chemical entities (NCEs).
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl (3R,4S)-3-Amino-4-Methylpyrrolidine-1-Carboxylate
CAS No.	1290191-85-3
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	1-Boc-3-amino-4-methylpyrrolidine (3R,4S)-enantiomer; (3R,4S)-1-(tert-Butoxycarbonyl)-3-amino-4-methylpyrrolidine; tert-Butyl (3R,4S)-3-amino-4-methyl-1-pyrrolidinecarboxylate; (3R,4S)-3-Amino-4-methylpyrrolidine-1-carboxylic acid tert-butyl ester; Boc-(3R,4S)-3-Amino-4-methylpyrrolidine; (3R,4S)-3-Amino-4-methylpyrrolidine, N-Boc protected; N-Boc-(3R,4S)-3-Amino-4-methylpyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,4S)-3-Amino-4-Methylpyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.