Description

1-Piperidinecarboxylic Acid, 4-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester, (3S,4R)- is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. This compound matters because it provides a critical, protected piperidine scaffold essential for constructing complex molecules with precise three-dimensional architecture. Pharmaceutical research and development teams need it for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce the (3S,4R)-configured 4-hydroxy-3-methylpiperidine moiety into target molecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and route development for potential Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Research: Potential application in the synthesis of inhibitors targeting specific enzymes.
• Chemical Biology: Can be utilized for the synthesis of molecular probes to study biological pathways and protein function.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester, (3S,4R)-
CAS No.	1290191-83-1
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(3S,4R)-tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate; (3S,4R)-1-Boc-4-hydroxy-3-methylpiperidine; (3S,4R)-N-Boc-4-hydroxy-3-methylpiperidine; (3S,4R)-4-Hydroxy-3-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (3S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-3-methylpiperidine; (3S,4R)-Boc-4-hydroxy-3-methylpiperidine; (3S,4R)-4-Hydroxy-3-methylpiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 4-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester, (3S,4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.