Description

(R)-3-Iodo-Pyrrolidine CAS NO 1289585-26-7 is a high-value, chiral pyrrolidine derivative featuring an iodine substituent at the 3-position, serving as a critical building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex, stereodefined molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and advanced material sectors who require high-purity, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Used in cross-coupling reactions (e.g., Negishi, Suzuki) and nucleophilic substitutions to introduce the pyrrolidine scaffold with defined stereochemistry.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Intermediate in the synthesis of novel, biologically active compounds for crop protection.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and receptor interactions.
• Material Science: Building block for functionalized polymers and advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	(R)-3-Iodo-Pyrrolidine
CAS No.	1289585-26-7
Molecular Formula	C4H8IN
Molecular Weight	197.02 g/mol
Synonyms	(R)-3-Iodopyrrolidine; (3R)-3-Iodopyrrolidine; (R)-3-Iodo-1-azacyclopentane; Pyrrolidine, 3-iodo-, (3R)-; (R)-(-)-3-Iodopyrrolidine; (R)-N-Iodopyrrolidine; 1289585-26-7; (R)-3-Iodoazolidine
EINECS	Contact for details

Quality Control

Our (R)-3-Iodo-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥97%), enantiomeric excess (ee), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.