Description

(1R,4R)-[4-(3-Nitro-Pyridin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex therapeutic areas. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of new drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel, high-value Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and route development of candidate drugs.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity due to its defined (1R,4R) stereochemistry.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the pharmaceutical industry.
• Reference Standard: Can be used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(1R,4R)-[4-(3-Nitro-Pyridin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester
CAS No.	1289386-01-1
Molecular Formula	C17H26N4O4
Molecular Weight	350.42 g/mol
Synonyms	(1R,4R)-N-[4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexyl]-3-nitro-2-pyridinamine; tert-Butyl N-[(1R,4R)-4-[(3-nitropyridin-2-yl)amino]cyclohexyl]carbamate; (1R,4R)-4-[(3-Nitro-2-pyridinyl)amino]cyclohexylcarbamic Acid 1,1-Dimethylethyl Ester; (1R,4R)-tert-Butyl (4-((3-nitropyridin-2-yl)amino)cyclohexyl)carbamate; BOC-Protected (1R,4R)-Cyclohexylamine Nitropyridine Derivative; CAS 1289386-01-1
EINECS	Contact for details

Quality Control

Our (1R,4R)-[4-(3-Nitro-Pyridin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.