Description

4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl-thiazole core, which imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, as well as by fine chemical manufacturers producing custom intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and antiviral programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands, organic electronic materials, and specialty polymers.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical suppliers to fulfill bespoke synthesis projects for clients in life sciences.
• Academic & Institutional Research: Utilized in university and government labs for methodological studies in fluorination and heterocyclic chemistry.

Basic Information

Product Name	4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester
CAS No.	1289104-53-5
Molecular Formula	C7H4F3NO2S
Molecular Weight	223.17 g/mol
Synonyms	Methyl 4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 5-Thiazolecarboxylic acid, 4-(trifluoromethyl)-, methyl ester; Methyl 4-trifluoromethylthiazole-5-carboxylate; 4-(Trifluoromethyl)thiazole-5-carboxylic acid methyl ester; 4-Trifluoromethyl-5-thiazolecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester adheres to stringent internal quality protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.